Publications

 

The Snutch Lab research focuses on molecular neurobiology, especially as it relates to voltage-gated calcium channels and central nervous system disorders. Following is a list of publications by Terrance P. Snutch et al. from 1983-present.

 

C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins. J Biol Chem2017 Apr 4. pii: jbc.M117.778829. doi: 10.1074/jbc.M117.778829. [Epub ahead of print] PMID: 28377503  Hirano M, Takada Y, Wong CF, Yamaguchi K, Kotani H, Kurokawa T, Mori MX, Snutch TP, Ronjat M, Waard M, Mori Y

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In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures. Proc. Natl. Acad. Sci., USA 2017 Feb 28;114(9):2401-2406. doi: 10.1073/pnas.1614447114. Epub 2017 Feb 21. PMID: 28223480.  Cain SM, Bohnet B, LeDue JM, Yung AC, Garcia E, Tyson JR, Alles SRA, Han H, Arn M.J.M. van den Maagdenberg AMJM, Kozlowski P, MacVicar BA, Snutch TP

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Heantos-4, a Natural Plant Extract used in the Treatment of Drug Addiction, Modulates T-type Calcium Channels and Thalamocortical Burst-Firing. Molecular Brain 9: 94 2016 Dec 5;9(1):94. doi: 10.1186/s13041-016-0274-7. PMID:27919294  Cain SM , Ahn S, Garcia E , Zhang Y, Waheed Z, Tyson JR, Yang Y, Van Sung T, Phillips AG and Snutch TP

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The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. Neuroscience. 2016 Sep 22;332:121-9. doi: 10.1016/j.neuroscience.2016.06.035. Epub 2016 Jun 27. PMID:27365170  Marks WN, Greba Q, Cain SM, Snutch TP, Howland JG.

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The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis. 2016 Jun 6. pii: S0969-9961(16)30134-6. doi: 10.1016/j.nbd.2016.06.001. [Epub ahead of print] PMID:27282256  Marks WN, Cain SM, Snutch TP, Howland JG.

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The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans. Eur J Neurosci. 2016 Jan;43(1):25-40. doi: 10.1111/ejn.13110. Epub 2015 Nov 25  PMID:26490879  Marks WN, Cavanagh ME, Greba Q, Cain SM, Snutch TP, Howland JG.
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MinION Analysis and Reference Consortium: Phase 1 data release and analysis [version 1; referees: 1 approved] F1000Research 2015, 4:1075(doi:10.12688/f1000research.7201.1) PMID:26834992
Camilla L.C. Ip*, Matthew Loose*, John R. Tyson*, Mariateresa de Cesare*, Bonnie L. Brown*, Miten Jain*, Richard M. Leggett*, David A. Eccles, Vadim Zalunin, John M. Urban, Paolo Piazza, Rory J. Bowden, Benedict Paten, Solomon Mwaigwisya, Elizabeth M. Batty, Jared T. Simpson, Terrance P. Snutch, Ewan Birney*, David Buck*, Sara Goodwin*, Hans J. Jansen*, Justin O’Grady*, Hugh E. Olsen*   * Equal contributors
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Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Sci Rep. 2015 Sep 18;5:13688. doi: 10.1038/srep13688. PMID:26381090
Poetschke C, Dragicevic E, Duda J, Benkert J, Dougalis A, DeZio R, Snutch TP, Striessnig J, Liss B.
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A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking. Mol Cell Neurosci. 2015 August 25;68:293-302. doi:10.1016/j.mcn.2015.08.012. PMID:26319746
Matschke LA, Bertoune M, Roeper J, Snutch TP, Oertel WH, Rinné S, Decher N.
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Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model. PLoS One. 2015 Aug 14;10(8):e0130012. doi: 10.1371/journal.pone.0130012. eCollection 2015. PMID:26274319
Casillas-Espinosa PM, Hicks A, Jeffreys A, Snutch TP, O’Brien TJ, Powell KL.
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CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Genes Dev. 2015 Jul 15;29(14):1535-51. doi: 10.1101/gad.260869.115. PMID:26220996
Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ.
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Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels. Neuroscience. 2015 Sep 24;304:198-208. doi: 10.1016/j.neuroscience.2015.07.044. Epub 2015 Jul 21. PMID:26208839
Kaja S, Payne AJ, Nielsen EØ, Thompson CL, van den Maagdenberg AM, Koulen P, Snutch TP.
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The Triggle effect. Biochem Pharmacol. 2015 Jul 20. pii: S0006-2952(15)00367-6. doi: 10.1016/j.bcp.2015.07.003. [Epub ahead of print] Review. PMID:26206192
Snutch TP, Zamponi GW. (2015)
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The cellular mechanisms of neuronal swelling underlying cytotoxic edema. Cell. Apr 23;161(3):610-21. doi.10.1016/j.cell.2015.03.029. PMID: 25910210
Rungta RL, Choi HB, Tyson JR, Malik A, Dissing-Olesen L, Lin PJ, Cain SM, Cullis PR, Snutch TP, MacVicar BA.(2015)
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The unusual suspects: Regulation of retinal calcium channels by somatostatin. Channels (Austin). 2015;9(2):61-2. doi: 10.1080/19336950.2015.1018000. PMID:25715059
Hildebrand ME, Snutch TP. (2015)
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Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels. Sci Signal. 2014 Oct 7;7(346):ra94. doi: 10.1126/scisignal.2005283.PMID:25292213
Zhang Y, Qin W, Qian Z, Liu X, Wang H, Gong S, Sun YG, Snutch TP, Jiang X, Tao J. (2014)
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Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels. Cell Calcium. 2014 Oct;56(4):285-95. doi: 10.1016/j.ceca.2014.09.002. Epub 2014 Sep 15. PMID:25260713
Ranzato E, Magnelli V, Martinotti S, Waheed Z, Cain SM, Snutch TP, Marchetti C, Burlando B.(2014)
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Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy. Pflugers Arch. 2015 Jun;467(6):1367-82. doi: 10.1007/s00424-014-1549-4. Epub 2014 Jun 24. PMID:24953239
Cain SM, Tyson JR, Jones KL, Snutch TP.(2014)
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Low threshold T-type calcium channels as targets for novel epilepsy treatments. Br J Clin Pharmacol. 2014 May;77(5):729-39. doi: 10.1111/bcp.12205. Review. PMID:23834404
Powell KL, Cain SM, Snutch TP, O’Brien TJ. (2014)
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Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers. Bioorganic and Medicinal Chemistry Letters 23:3257-3261.PMID:23639535
Borzenko A, H Pajouhesh, JL Morrison, E Tringham, TP Snutch, LL Schafer (2013)
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Advances in voltage-gated calcium channel structure, function and physiology.  Biochimica Biophysica Acta 1828:1521. PMID:23518035
Zamponi, GW & TP Snutch (2013)
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Modulation of low-voltage-activated T-type Ca(2+) channels. Biochimica Biophysica Acta 1828:1550-1559. PMID: 22975282
Zhang, Y, X Jiang, TP Snutch, J Tao (2012)
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T-type calcium channels in burst-firing, network synchrony, and epilepsy. Biochimica Biophysica Acta 1828:1572-1578.PMID22885138
Cain, SM & TP Snutch (2012)
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Voltage-Gated Calcium Channels in Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper’s Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. PMID:22787663
Cain SM, Snutch TP.(2012)
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Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett. 22:4153-4158. PMID:22579422 
Pajouhesh, H, ZP Feng, L Zhang, H Pajouhesh, X Jiang, A Hendricson, H Dong, E Tringham, Y Ding , TW Vanderah, F Porreca, F Belardetti F, GW Zamponi, LA Mitscher, TP Snutch (2012)
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T-Type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Science Translational Medicine 4:121ra19. PMID:22344687
Tringham, E, KL Powell, SM Cain, K Kuplast, J Mezeyova, M Weerapura, C Eduljee, X Jiang, P Smith, J-L Morrison, NC Jones, E Braine, G Rind, M Fee-Maki, D Parker, H Pajouhesh, M Parmar, TJ O’Brien, TP Snutch (2012)

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Repression of the potassium channel by nuclear hormone receptor and TGF-beta signaling modulates insulin signaling in Caenorhabditis elegans. PLoS Genet. 2012;8(2):e1002519. doi: 10.1371/journal.pgen.1002519. Epub 2012 Feb 16. PMID:22359515 
Park, D, KL Jones, H Lee, TP Snutch, S Taubert, DL Riddle (2012)
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Characterization of the substituted N-triazole oxindole, TROX-1, a small molecules, state-dependent inhibitor of Cav2 calcium channels. Molecular Pharmacology, in press. PMID 22188924.

Swensen, AM, J Herrington, RM Bugianesi, G Dai, RJ Haedo, KS Ratliff, MM Smith, VA Warren, SP Arneric, C Eduljee, D Parker, TP Snutch, SB Hoyt, C London, JL Duffy, GJ Kaczorowski, OB McManus (2011)
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Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons. Molecular Pain 7:67. PMID:21910862 
Hildebrand, ME, J Mezeyova, PL Smith, MW Salter, E Tringham and TP Snutch (2011)
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Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels. Journal of Neurochemistry. 119: 826-847 PMID:21883225
Gonzalez, LE, ML Kotler, LG Vattino, E Conti, RC Reisin, KJ Mulatz, TP Snutch and OD Uchitel (2011)
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T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci U S A. 108: 11268-11273. PMID21690417 
Marger F, A Gelot, A Alloui, J Matricon, JF Ferrer, C Barrère, A Pizzoccaro, E Muller, J Nargeot, TP Snutch, A Eschalier, E Bourinet, D Ardid (2011)
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Voltage-gated calcium channels and disease. Biofactors 37: 197-205.
Cain, SM and TP Snutch (2011) PMID:21698699
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Voltage-gated calcium channels in epilepsy. Jasper’s Basic Mechanisms of the Epilepsies (4th Edition). Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds. Published by Oxford University Press. P. 66-84. PMID:22787663
Cain, SM and TP Snutch (2011)
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A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain. Pain 152 (2011) 833–843. PMID: 21349638.
Hildebrand, ME, PL Smith, C Bladen, C Eduljee, JY Xie, L Chen, M Fee-Maki, CJ Doering, J Mezeyova, Y Zhu, F Belardetti, H Pajouhesh, D Parker, S Arneric, M Parmar, F Porecca, E Tringham, GW Zamponi and TP Snutch (2011)
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Voltage-gated calcium channels in epilepsy. Epilepsia 51(Suppl. 5): 11.
Cain, SM and TP Snutch (2010) PMID:22787663
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Contributions of T-type calcium channel isoforms to neuronal firing. Channels. 4(6): 475-482. PMID21139420
Cain SM and TP Snutch (2010)
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Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel. Proc Natl Acad Sci U S A.107:18694-18699. PMID20937883
Adams, PJ, RL Rungta, E Garcia, AM van den Maagdenberg, BA MacVicar and TP Snutch (2010)
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Contributions of T-Type Voltage-Gated Calcium Channels to Postsynaptic Calcium Signaling within Purkinje Neurons. Cerebellum. 2010 Aug 24.
Isope, P, ME Hildebrand and TP Snutch (2010) PMID20734177
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Splice-variant changes of the Ca(V)3.2 T-type calcium channel mediate voltage-dependent facilitation and associate with cardiac hypertrophy and development. Channels 4(5): 375 – 389. PMID20699644
David, LS, E Garcia, SM Cain, EM Thau, Tyson JR and TP Snutch (2010)
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The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. British Journal of Pharmacology 160:1464-1475. PMID20590636
Singh, A, ME Hildebrand, E Garcia, TP Snutch (2010)
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Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependant Cav2 Calcium Channel Blocker. Journal of Pharmacology Experimental Therapeutics 334:545-555.
Abbadie, C, OB McManus, SY Sun, RM Bugianesi, G Dai, RJ Haedo, JB Herrington, GJ Kaczoroski, MM Smith, AM Swensen, VA Warren, B Williams, SP Arneric, C Eduljee, TP Snutch, EW Tringham, N Jochnowitz, A Liang, E Macintyre, E McGowan, S Mistry, VV White, SB Hoyt, C London, KA Lyons, PB Bunting, S Volksdorf, JL Duffy (2010)
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Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorganic and Medicinal Chemistry Letters 20: 1378-83. Epub 2010 Jan 7
Pajouhesh, H, ZP Feng, Y Ding, L Zhang, H Pajouhesh, JL Morrison, F Belardetti, E Tringham, E Simonson, TW Vanderah, F Porreca, GW Zamponi, LA Mitscher, TP Snutch (2010)
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Treatments for Neuropathic Pain Differentially Affect Delayed Matching Accuracy by Macaques: Effects of Amitriptyline and Gabapentin. Pain 148:446-453. Epub 2010 Jan 25
Buccafusco, JJ, AV Terry, Jr., A Vazdarjanova, TP Snutch and SP Arneric (2009)
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Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorganic and Medicinal Chemistry Letters 19: 6467-6472
Zamponi, GW, ZP Feng, L Zhang, H Pajouhesh, Yanbing Ding, F Belardetti, H Pajouhesh, D Dolphin, LA Mitscher and TP Snutch (2009)
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Functional Coupling Between mGluR1 and Cav3.1 T-type Calcium Channels Enhances Cerebellar Purkinje Cell Excitability and Local Signaling. Journal of Neuroscience 29:9668-9682.
Hildebrand, ME, P Isope, E Garcia, A Feltz, T Schneider, J Hescheler, M Kano, K Sakimura, S Dieudonne, TP Snutch (2009)
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A Fluorescence-based High Throughput Screening Assay for the Identification of T-type Calcium Channel Blockers. Assay and Drug Development Technologies 7:266-280
Belardetti, F., Tringham, E., Eduljee, C., Dong, H., Hendricson, A., Shimizu, Y., Janke, D.L., Parker, D., Mezeyova, J., Pajouhesh, H., Fraser, R.A., Arneric, S.P., and Snutch, T.P. (2009)
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Block of voltage-gated calcium channels stimulates dopamine release in rat mesocorticolimbic system. Neuropharmacology 56: 984-993.
Belardetti F, S Ahn, K So, TP Snutch and AG Phillips (2009)
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Cav2.1 P/Q-type Calcium Channel Alternative Splicing Affects the Functional Impact of Familial Hemiplegic Migraine Mutations: Implications for Calcium Channelopathies. Channels 3(2): 110-121.
Adams, PJ, E Garcia, LS David, KJ Mulatz, SD Spacey and TP Snutch (2009)
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Voltage-Gated N- type and T-type Calcium Channels and Excitability Disorders. In Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels. (Edited by VK Gribkoff and L Kaczmarek ). John Wiley & Sons, Inc. P. 35-66.
Tringham, E and TP Snutch (2009)

Role of voltage calcium channels in ascending pain pathway. Brain Research Reviews 60(1):84-9
Zamponi, GW, RJ Lewis, SM Todorovic, SP Arneric, TP Snutch (2009)
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A Cav3.2 T-type calcium channel point mutation has splice variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. Journal of Neurosci., 29:371-380.
Powell, KL, SM Cain, C Ng, S Sirdesai, LS David, M Kyi, E Garcia, JR Tyson, CA Reid, M Bahlo, SJ Foote, TP Snutch, TJ O’Brien (2008)
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Block of Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration and Relapse. Journal of Neuroscience 28(45): 11712-11719.
Newton, PM, L Zeng, V Wang, J Connolly, MJ Wallace, CK Kim, HS Shin, F Belardetti, TP Snutch, RO Messing (2008)
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Activation of corticotropin-releasing factor receptor 1 selectively inhibits Cav3.2 T-type calcium channels. Mol Pharmacol. 73: 1596-1609.
Tao, J, ME Hildebrand, P Liao, MC Liang, G Tan, S Li, TP Snutch, and TW Soong (2008)
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Molecular mechanism of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. Journal of Neuroscience, 27:12577-12583.
Nelson, MT, PM Joksovic, P Su, HW Kang, AV Deusen, JP Baumgart, LS David, TP Snutch, PQ Barrett, J-H Lee, CF Zorumski, E Perez-Reyes and SM Todorovic (2007)
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Calcium Channelopathies: Voltage-gated Calcium Channels (2007) Subcellular Biochemistry, 45: 215-251.
Adams, PJ and TP Snutch (2007)
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UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Current Biology, 17: 1595-1600.
Jospin,M, S Watanabe, D Joshi, S Young, K Hamming, C Thacker, TP Snutch, EM Jorgensen and K Schuske (2007)
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Selective Inhibition of Cav3.3 T-type Ca Channels by Gαq/11-Coupled Muscarinic Acetylcholine Receptors. Journal of Biological Chemistry, 282:21043-21055.
Hildebrand, ME, LS David, J Hamid, K Mulatz, E Garcia, GW Zamponi and TP Snutch (2007)
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The Sodium “Leak” Has Finally Been Plugged. Neuron, 54: 505-507.
Snutch, TP and A Monteil (2007)
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A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Current Biology, 17:624-629
Humphrey, JA, KS Hamming, CM Thacker, RL Scott, MM Sedensky, TP Snutch, PG Morgan and HA Nash (2007)
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Leftward Shift in the Voltage-Dependence for Ca2+ Currents Activation Induced by a New Toxin from Phoneutria reidyi (Aranae, Ctenidae) Venom. Cell. Moll. Neurobiol., 27(1) 129-146.
Vieira, LB, AM Pimenta, M Richardson, MP Bemquerer, HJ Reis, JS Cruz, MV Gomez, MM Santoro, R Ferreira-de-Oliveira, SG Figueiredo, TP Snutch, and MN Cordeiro (2007)
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CaV3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci. 24: 2581-2594.
BE McKay, JE McRory, ML Molineux, J Hamid, TP Snutch, GW Zamponi, and RW Turner (2006)
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Contributions of T-type Ca channels to the pathophysiology of pain signaling. Drug Discovery Today: Disease Mechanisms, 3:335-341
Hildebrand, ME and TP Snutch (2006)

Temperature dependence of T-type calcium channel gating. Neuroscience, 142:1031-1042.
Iftinca, M, McKay, BE, Snutch, TP, McRory, JE, Turner RW and Zamponi, GW (2006)
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T-type Calcium Channels: An Emerging Therapeutic Target for the Treatment of Pain. Drug Development Research, 67:404-415.
Snutch, TP and L David (2006)
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Genetic heterogeneity in paroxysmal nonkinesigenic dyskinesia. Neurology, 66: 1588-1590
Spacey, SD, PJ Adams, PCP Lam, LA, Materek, J Stoessl, TP Snutch and G-YR Hsiung (2006)
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N-type Calcium Channels. In Voltage-Gated Ion Channels as Drug Targets (Edited by D Triggle, M Gopalakrishnan, D Rampe and W Zheng). Wiley-VCH. P. 122-149.
SNUTCH, TP (2006)

Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proc. Natl. Acad Sci. (USA), 103(14): 5555-5560.
Molineux, M, JE McRory, BE McKay, J Hamid, WH Mehaffey, TP Snutch, GW Zamponi and RW Turner (2006)
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Functional Analysis of Cav3.2 T-type calcium channel mutations linked to childhood absence epilepsy. Epilepsia, 47(3): 655-658.
Peloquin, JB, H Khosravani, W Barr, C Bladen, R Evans, J Mezeyova, D Parker, TP Snutch, JE McRory and GW Zamponi (2006)
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International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels. Pharmacological Reviews, 57: 411-425.
Catterall, WA, E Perez-Reyes, TP Snutch and J Striessnig (2005)
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Targeting Chronic and Neuropathic Pain: The N-type Calcium Channel Comes of Age. NeuroRx, 2(4): 662-670.
SNUTCH, TP (2005)
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Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates a major role in nociception. EMBO Journal, 24:315-324.
Bourinet, E, A Alloui, A Monteil, C Barrere, B Couette, O Poirot, A Pages, J McRory, TP Snutch, A Eschalier and J Nargeot (2005)
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Inhibition of High Voltage-Activated Calcium Channels by Spider Toxin, PnTx3-6. Journal of Pharmacology and Experimental Therapeutics,314: 1370-1377.
Vieira LB, Kushmerick C, Hildebrand ME, Garcia E, Cordeiro MN, Richardson M, Gomez, MV and TP Snutch (2005)
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The C. elegans T-type Ca channel CCA-1 boosts neuromuscular transmission. Journal of Experimental Biology, 208:2191-2203.
Steger, KA, BB Shtonda, C Thacker, TP Snutch and L Avery (2005)
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Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy. Annals of Neurology, 57(5):745-9.
Khosravani, H, C Bladen, D Parker, TP Snutch and GW Zamponi (2005)
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Molecular Properties of Voltage-Gated Calcium Channels. In Channels Voltage-Gated Calcium (Edited by Gerald Zamponi). Landes Bioscience. P.61-94.
Snutch, TP, J Peloquin, E Mathews, and J McRory (2005)

Malaysian Siblings with Friedreich Ataxia and Chorea: A Novel Deletion in Frataxin Gene. Canadian Journal of Neurological Sciences, 31: 383-386.
Spacey, SD, BI Szczygielski, SP Young, J Hukin, K Selby and TP SNUTCH (2004)
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Functional implications of a novel EA2 mutation in the P/Q-type calcium channel. Annals of Neurology. 56(2):213-220.
Spacey, S, ME Hildebrand, LA Materek, TD Bird, and TP SNUTCH (2004)
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The CACNA1F gene implicated in congenital night blindness encodes an L-type calcium channel with unique biophysical properties and tissue distribution. Journal of Neuroscience, 24(7):1707-1718.
McRory, JE, J Hamid, CJ Doering, E Garcia, R Parker, K Hamming, L Chen, M Hildebrand, A Beedle, L Feldcamp, GW Zamponi and TP SNUTCH (2004)
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Gating effects of mutations in the Cav3.2 T-type calcium channel associated with Childhood Absence Epilepsy. Journal of Biological Chemistry, 279(11):9681-9684.
Khosravani, H, C Altier, B Simms, KS Hamming, J Mezeyova, TP SNUTCH, JE McRory, and GW Zamponi (2004)
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Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin. Journal Pharmacology and Experimental Therapeutics, 308(3):805-13.
Hildebrand, ME, JE McRory, TP SNUTCH and A Stea (2004)
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International Union of Pharmacology. XL. Compendium of Voltage-Gated Ion Channels: Calcium Channels. Pharmacological Reviews, 55(4)579-581.
Catterall, WA, J Striessnig, TP SNUTCH and E Perez-Reyes (2003)
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Molecular and functional insights into voltage-gated calcium channels. In Molecular Insights Into Ion Channel Biology in Health and Disease (Edited by Bob Maue). Elsevier B.V. Chapter 16, p 379-405.
Stea, A and TP SNUTCH (2003).

Pseudomigraine with Lymphocytic Pleocytosis – A Calcium Channelopathy? Clinical Description of 10 Cases and Genetic Analysis of the Familial Hemiplegic Migraine Gene CACNA1A, Headache. 43(8):892-895.
Chapman, KM, BI Szczygielski, A Woolfenden, C Toth, G Robinson, TP SNUTCH and S Spacey (2003)
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Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties. Journal of Neuroscience. 23(16): 6537-45.
Mathews, EA, E Garcia, CM Santi, GP Mullen, C Thacker, DG Moerman and TP SNUTCH (2003)
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Signalling Mechanisms. Current Opinion in Neurobiology, 13: 261-263.
Sheng, M and TP SNUTCH (2003)

The IUPHAR Compendium of Voltage-Gated Ion Channels. Edited by WA Catterall, KG Chandy, GA Gutman. P. 44-50.
SNUTCH, TP (2002)

Modulating Modulation: Crosstalk between regulatory pathways of presynaptic Ca channels. Molecular Interventions. 2: 476-478.
Zamponi, GW and TP SNUTCH (2002)
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Mutation Analysis of the Sodium/Hydrogen Exchanger Gene (NHE5) in Familial Paroxysmal Kinesigenic Dyskinesia, Journal of Neural Transmission 109: 1189-1194.
Spacey, SD, BI Szczgielski, JE McRory, GM Wali, NW Wood and TP SNUTCH (2002)
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Differential Inhibition of T-type Calcium Channels by Neuroleptics. Journal of Neuroscience 22(2): 396-403.
Santi, CM, FS Cayabyab, KG Sutton, JE McRory, J Mezeyova, KS Hamming, D Parker, A Stea and TP SNUTCH (2002)
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Gabapentin: A novel analgesic targeting voltage-gated calcium channels. Drug Development Research 54(3): 167-172.
Sutton, K and TP SNUTCH, (2002)

Residue G1326 of the N-type calcium channel α1B subunit controls reversibility of ϖ-conotoxin GVIA and MVIIA block. Journal of Biological Chemistry 276: 15728-15735.
Feng, Z-P, J Hamid, C Doering, GM Bosey, TP SNUTCH, and GW Zamponi (2001)
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Molecular and functional characterization of family of rat brain T-type calcium channels. Journal of Biological Chemistry 276: 3999-4011.
McRory, JE, CM Santi, KSC Hamming, J Mezeyova, KG Sutton, DL Baillie, A Stea, and TP SNUTCH (2001)
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Amino acid residues outside of the pore region contribute to N-type calcium channel permeation. Journal of Biological Chemistry 276: 5726-5730.
Feng Z-P, J Hamid, C. Doering, SE Jarvis, GM Bosey, E Bourinet, TP SNUTCH and GW Zamponi (2001)
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Voltage-dependent calcium channels – Beyond dihydropyridine antagonists. Current Opinion in Pharmacology 1: 11-16.
SNUTCH, TP, KG Sutton and GW Zamponi (2001)
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Voltage-gated calcium channels direct neuronal migration in Caenorhabditis elegans. Developmental Biology 226: 104-117.
Tam, T, E Mathews, TP SNUTCH and WR Schafer (2000)
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Nomenclature of voltage-gated calcium channels. Neuron 25(3): 533-5.
Ertel, E, KP Campbell, MM Harpold, F Hoffmann, Y Mori, E Perez-Reyes, A Schwartz, TP SNUTCH, T Tanabe, L Birnbaumer, RW Tsien and WA Catterall (2000)

Determinants of voltage-dependent inactivation affect mibefradil block of calcium channels. Neuropharmacology 39: 1-10.
Jimenez, C, E Bourinet, V Leuranguer, S Richard, TP SNUTCH and J Nargeot (2000)
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A new β subtype-specific interaction in α1A subunit controls P/Q-type Ca2+ channel activation. Journal of Biological Chemistry 274: 12383-12390.
Walker, D, D Bichet, S Geib, E Mori, V Cornet, TP SNUTCH, Y Mori and M De Waard (1999)
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P/Q-type Ca2+ channels mediate the activity dependent feedback of syntaxin-1A. Nature 401: 800-804.
Sutton, KG, JE McRory, H Guthrie, TH Murphy and TP SNUTCH (1999)
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Volatile anesthetic inhibition of neuronal Ca channel currents expressed in Xenopus oocytes. Brain Research 831: 85-96.
Kamatchi, GL, CK Chan, TP SNUTCH, ME Durieux and C Lynch III (1999)
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Phenotypic variants of P- and Q-type calcium channels are generated by alternative splicing of the α1A subunit gene. Nature Neuroscience 2: 407-415.
Bourinet, E, TW Soong, K Sutton, S Slaymaker, E Mathews. A Monteil, GW Zamponi, J Nargeot and TP SNUTCH (1999)
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Identification of an integration centre for PKC and G protein modulation of N-type calcium channels. Journal of Biological Chemistry 274: 6195-6202.
Hamid, J, D Nelson, R Spaetgens, SJ Dubel, TP SNUTCH and GW Zamponi (1999)
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α1B N-type calcium channel isoforms with distinct biophysical properties. Annals of the New York Academy of Sciences 868: 118-130.
Stea, A, SJ Dubel and TP SNUTCH (1999)
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Decay of prepulse facilitation during G-protein inhibition of N-type calcium channels involves binding of a single Gβγ subunit. Proc. Natl. Acad. Sci. USA 95: 4035-4039.
Zamponi, GW and TP SNUTCH (1998)
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Modulation of voltage-dependent calcium channels by G proteins. Current Opinion in Neurobiology 8: 351-356.
Zamponi, GW and TP SNUTCH (1998)
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The permeation properties of α1E Ca channels are similar to a subset of low threshold calcium channels. In Low-Voltage-Activated T-type Calcium Channels. Edited by Tsien, Clozel and Nargeot. p. 92-98.
Bourinet, E, GW Zamponi, J Nargeot and TP SNUTCH (1998)

Limitations of nickel ions as a tool for discrimination between high and low threshold calcium channels. In Low-Voltage-Activated T-type Calcium Channels. Edited by Tsien, Clozel and Nargeot. p. 251-257.
Zamponi, GW, E Bourinet and TP SNUTCH (1998)

Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW 13.3. Molecular Pharmacology 54: 407-418.
Sutton, K, C Siok, A Stea, G Zamponi, S Heck, RA, Volkmann, M Ahlijanian and TP SNUTCH (1998)
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Cross talk between G-proteins and protein kinase C mediated by the calcium channel α1 subunit. Nature 385: 442-446.
Zamponi, GW, E Bourinet, D Nelson, J Nargeot and TP SNUTCH (1997)
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L-type calcium channels regulate gastrin release from human antral G cells. American Journal of Physiology 273: 281-288.
Ray, JM, PE Squires, RM Meloche, DW Nelson, TP SNUTCH and AMJ Buchan (1997)
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Molecular cloning of a mammalian homologue of the yeast vesicular transport protein vps45. Biochimica et Biophysica Acta 1325: 8-12.
El-Husseini, AED, H Guthrie, TP SNUTCH and SR Vincent (1997)
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Structure and Function of Ca2+ Channels. Trends in Pharmacological Sciences, Receptor and Ion Channel Supplement.
TP SNUTCH and MM Gilbert (1997)

Bursts of action potential waveforms relieve G-protein inhibition of recombinant P/Q-type Ca2+ channels in HEK 293 cells. Journal of Physiology 499: 637-644.
Brody, DL, PG Patil, JG Mulle, TP SNUTCH and DT Yue (1997)
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G-protein modulation of N-type calcium channel gating current in human embryonic kidney cells. Journal of Physiology 498: 601-610.
Jones, LP, PG Patil, TP SNUTCH and DT Yue (1997)
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Elementary events underlying voltage-dependent G-protein inhibition of N-type calcium channels. Biophysical Journal 71: 2509-2521.
Patil, PG, M de Leon, RR Reed, SJ Dubel, TP SNUTCH and DT Yue (1996)
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The α1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels. Journal of Neuroscience 16: 4983-4993.
Bourinet, E, GW Zamponi, A Stea, TW Soong, BA Lewis, LP Jones, DT Yue and TP SNUTCH (1996)
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Isoform-specific interaction of the α1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25. Proc. Natl. Acad. Sci. USA 93: 7363-7368.
Rettig, J, ZH Sheng, DK Kim, CD Hodson, TP SNUTCH and WA Catterall (1996)
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Nickel block of a family of neuronal calcium channels: subtype and subunit-dependent action at multiple sites. Journal of Membrane Biology 151: 77-90.
Zamponi, GW, E Bourinet and TP SNUTCH (1996)
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Evidence for a specific site for modulation of calcium channel activation by external calcium. Pflugers Archiv – European Journal of Physiology 431: 470-472.
Zamponi, GW and TP SNUTCH (1996)
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β subunit coexpression and the α1 subunit domain I-II linker affect piperidine block of neuronal calcium channels. Journal of Neuroscience 16: 2430-2443.
Zamponi, GW, TW Soong, E Bourinet and TP SNUTCH (1996)
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Determinants of the G-protein-dependent opioid modulation of neuronal calcium channels. Proc. Natl. Acad. Sci. USA 93: 1486-1491.
Bourinet, E, TW Soong, A Stea and TP SNUTCH (1996)
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An essential Ca2+-binding motif for Ca2+-sensitive inactivation of L-type Ca2+ channels. Science 270: 1502-1506.
de Leon, M, L Jones, E Perez-Reyes, X Wei, TW Soong, TP SNUTCH and DT Yue (1995)
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Determinants of PKC-dependent modulation of a family of neuronal calcium channels. Neuron 15: 929-940.
Stea, A, TW Soong and TP SNUTCH (1995)
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Biochemical properties and subcellular distribution of the neuronal class E calcium channel α1 subunit. Journal of Neuroscience 15: 6419-6432.
Yokoyama, CT, RE Westenbroek, JW Hell, TW Soong, TP SNUTCH and WA Catterall (1995)
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Immunochemical identification and subcellular distribution of the α1 subunit of neuronal class A calcium channels. Journal of Neuroscience 15: 6403-6418.
Westenbroek, RE, T Sakurai, EM Elliott, JW Hell, TVB Starr, TP SNUTCH and WA Catterall (1995)
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Voltage-dependent facilitation of a neuronal α1C L-type calcium channel. EMBO Journal 21: 5032-5039.
Bourinet, E, P Charnet, WJ Tomlinson, A Stea, TP SNUTCH and J Nargeot (1994)
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Calcium currents recorded from a neuronal α1C L-Type calcium channel. FEBS Lett. 344: 87-90.
Charnet, P, E Bourinet, SJ Dubel, TP SNUTCH and J Nargeot (1994)
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The localization and functional properties of a rat brain α1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc. Natl. Acad. Sci. USA 91: 10576-10580.
Stea, A, WJ Tomlinson, TW Soong, E Bourinet, SJ Dubel, SR Vincent and TP SNUTCH (1994)
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Voltage-gated calcium channels. In: Handbook on Ion Channels. RA North (ed), CRC Press, p.113-151.
Stea, A, TW Soong and TP SNUTCH (1994)

The naming of voltage-gated calcium channels. Neuron 13: 505-506.
Birnbaumer, L, KP Campbell, WA Catterall, MM Harpold, F Hofmann, WA Horne, Y Mori, A Schwartz, TP SNUTCH, T Tanabe and RW Tsien (1994)

Calcium channel β subunit binds to a conserved motif in the I-II cytoplasmic linker of the α1 subunit. Nature 368: 67-70.
Pragnell, M, M De Waard, Y Mori, T Tanabe, TP SNUTCH and KP Campbell (1994)
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Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel α1 subunits. Journal of Cell Biology 123: 949-962.
Hell, JW, RE Westenbroek, C Warner, MK Ahlijanian, W Prystay, MM Gilbert, TP SNUTCH and WA Catterall (1993)
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Functional properties of a neuronal class C L-type calcium channel. Neuropharmacology 32: 1117-1126.
Tomlinson, WJ, A Stea, E Bourinet, P Charnet, J Nargeot and TP SNUTCH (1993)
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A β subunit normalizes the electrophysiological properties of a cloned N-type Ca2+ channel α1 subunit. Neuropharmacology 32: 1103-1116.
Stea, A, SJ Dubel, M Pragnell, JP Leonard, KP Campbell and TP SNUTCH (1993)
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Structure and functional expression of a member of the low voltage-activated calcium channel family. Science 260: 1133-1136.
Soong, TW, A Stea, CD Hodson, SJ Dubel, SR Vincent and TP SNUTCH (1993)
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Molecular properties of calcium channels in skeletal muscle and neurons. Annals N.Y. Acad. Sci. 681: 342-355.
Catterall, WA, K De Jongh, E Rotman, J Hell, R Westenbroek, S Dubel and TP SNUTCH (1993)

Differential phosphorylation of two size forms of the neuronal class C calcium channel α1 subunit. Journal Biol. Chem. 268: 19451-19457.
Hell, JW, CT Yokoyama, ST Wong, C Warner, TP SNUTCH and WA Catterall (1993)
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Calcium channels: diversity of form and function. Current Opinion in Neurobiology 2: 247-253.
SNUTCH, TP and PB Reiner (1992)
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Molecular cloning of the α1 subunit of an omega-conotoxin-sensitive calcium channel. Proc. Natl. Acad. Sci. (USA) 89: 5058-5062.
Dubel, SJ, TVB Starr, J Hell, MK Ahlijanian, JJ Enyeart, WA Catterall and TP SNUTCH (1992)
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Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma. Mayo Clinic Proceedings 67: 1150-1159.
Oguro-Okano, M, GE Griesmann, ED Wieben, SJ Slaymaker, TP SNUTCH and VA Lennon (1992)
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Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit. Neuron 9: 1099-1115.
Westenbroek, RE, JW Hell, C Warner, SJ Dubel, TP SNUTCH and WA Catterall (1992)
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Tissue RNA as a source of exogenous ion channels and receptors. Methods in Enzymology 207: 297-309.
SNUTCH, TP and G Mandel (1992).
Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Proc. Natl. Acad. Sci., (USA) 88: 5621-5625.
Starr TVB, W Prystay and TP SNUTCH (1991)
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Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS. Neuron 7: 45-57.
SNUTCH, TP, WJ Tomlinson, JP Leonard and MM Gilbert (1991)
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The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked. Molecular Brain Research 11: 143-149.
Yu, L, H Nguyen, H Lee, LJ Bloem, CA Kozak, BJ Hoffman, TP SNUTCH, HA Lester, N Davidson and H Lubbert (1991)
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Golf in the basal ganglia. Molecular and Cellular Neurosciences 2: 66-70.
Drinnan, SL, BT Hope, TP SNUTCH and SR Vincent (1991).

Expression of neurotransmitter receptors and ion channels in Xenopus oocytes. In: Molecular Neurobiology: A Practical Approach. IRL Press, pp. 161-182.
Leonard, JP and TP SNUTCH. (1991)

Rat brain expresses a heterogeneous family of calcium channels. Proc. Natl. Acad. Sci. (USA) 87: 3391-3395.
SNUTCH TP, JP Leonard, MM Gilbert, HA Lester and N Davidson (1990)
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Expression of mRNA encoding voltage-dependent Ca channels in Xenopus oocytes. Annals N.Y. Acad. Sci. 560: 174-182.
Lester HA, TP SNUTCH, JP Leonard, J Nargeot, N Dascal, BM Curtis and N Davidson (1989)

Expression of mRNA encoding rat brain Ca channels in Xenopus oocytes. In: The Calcium Channel: Structure, Function and Implications. Edited by M Morad, WG Nayler, S Kazda and M Schramm, Springer, p. 272-280.
Lester HA, TP SNUTCH, JP Leonard, J Nargeot and N Davidson (1988)

The Caenorhabditis elegans hsp70 gene family: a molecular genetic characterization. Gene 64: 241-255.
SNUTCH TP, MFP Heschl and DL Baillie (1988)
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13 07.
Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA isolated from electrically excitable tissues. In: Cell Calcium and Membrane Transport. Edited by L Mandel and D Eaton, Society of General Physiologists Series, Vol. 42, Rockefeller University Press, p. 153-166.
SNUTCH TP, JP Leonard, J Nargeot, H Lubbert, N Davidson and HA Lester (1987)

Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes. Journal of Neurosci. 8: 2859-2868.
Krafte DS, TP SNUTCH, JP Leonard, N Davidson and HA Lester (1988)
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The use of Xenopus oocytes to probe synaptic communication. Trends in Neurosci. 11: 250-256.
SNUTCH TP (1988)

cDNA cloning of a serotonin 5HT-1C receptor using electrophysiological assay of mRNA injected Xenopus oocytes. Proc. Natl. Acad. Sci. (USA) 84: 4332-4336.
Lubbert H, BJ Hoffman, TP SNUTCH, T van Dyke, AJ Levine, PR Hartig, HA Lester and N. Davidson (1987)
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Rat brain 5HT-1C receptors are encoded by a 5-6 kb mRNA size class and functionally expressed in Xenopus oocytes. Journal of Neurosci. 7: 1159-1165.
Lubbert H, TP SNUTCH, N Dascal, HA Lester and N Davidson (1987)
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14 02.
Calcium channels induced in Xenopus oocytes by injection of rat brain mRNA. Journal of Neurosci. 7: 875-881.
Leonard JP, J Nargeot, TP SNUTCH, N Davidson and HA Lester (1987)
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mRNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc. Natl. Acad. Sci. (USA) 83: 7503-7507.
Goldin AL, TP SNUTCH, H Lubbert, A Dowsett, J Marshall, V Auld, W Downey, RC Fritz, HA Lester, R Dunn, WA Catterall and N Davidson (1986)
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Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes. Science 231: 1147-1150.
Dascal N, TP SNUTCH, H Lubbert, N Davidson and HA Lester (1986)
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Involvement of a GTP-binding in mediation of the serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain mRNA. Brain Research 1: 201-209.
Dascal N, C Ifune, R Hopkins, TP SNUTCH, H Lubbert, N Davidson, MI Simon and HA Lester (1986)
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Isolation of the closed circular form of the transposable element, Tc1, in Caenorhabditis elegans. Nature 311: 485-486.
Rose AM and TP SNUTCH (1984)
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A high degree of DNA strain polymorphism associated with the major heat shock gene of Caenorhabditis elegans. Molecular and General Genetics 195: 329-335.
SNUTCH TP and DL Baillie (1984)
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Alterations in the pattern of gene expression following heat shock in Caenorhabditis elegans. Can. J. Biochem. Cell Biol. 61: 480-487.
SNUTCH TP and DL Baillie (1983)
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